This book is the result of research for development activities implemented from 2013 to 2016 in Central Mekong Action Area of Humidtropics, the CGIAR Research Program on Integrated Systems for the Humid Tropics. The objective of this book is to demonstrate achievements made, as well as challenges faced, while implementing integrated systems research to promote sustainable development of smallholder farming in the uplands of the Mekong region. The book is organized around three research themes: a) Systems analysis and synthesis, establishing baselines and conducting situation analysis to identify interventions; b) Integrated systems improvement in practice, the various interventions undertaken to promote environmentally sustainable smallholder agriculture; and c) Nutrition dimensions, the challenges of ensuring incorporation of nutrition within the production and livelihood systems.